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CCSB - Center for Cancer Systems Biology

Research


The overall goal of our research is to understand how macromolecular networks control biological processes and how perturbations of these networks relate to phenotypic changes and disease. Macromolecules do not function is isolation and binary protein-protein interactions are fundamental for all biological processes. To understand how proteins function in complex networks we have developed a robust high-throughput pipeline to map protein-protein interactions at proteome scale and to generate interactome maps. Using the same pipeline we can also explore the effect of genetic variants on the interaction profiles of proteins associated with human disease. 

In the interactive environment at CCSB all research projects are highly collaborative and people readily intermingle from one line of research to another. Currently research at CCSB can be roughly organized into the interdependent projects below. Research direction is provided and supervised by the CCSB Directors and Management Team. Affiliated CCSB Core Members widen the core mission of CCSB with their diverse expertise in related aspects of systems biology.






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