The Center for Cancer Systems Biology (CCSB) was founded in 2004 to bring together a diverse group of scientists with a broad range of cross-disciplinary interests and skills. What we all share is a common vision that to better understand the relationship between genotype to phenotype we must consider molecules not in isolation but in the context of the whole cell and in the network of interactions occurring within the cell, or as a system. Our aim is to understand how macromolecular networks control biological processes and how perturbations in these networks can explain phenotypes and human disease.
The long-term goal of CCSB is to understand how macromolecular networks control biological processes and how we can better understand human disease through perturbations of such networks. Physical protein-protein interactions are instrumental for all biological processes. We address several fundamental questions regarding protein interactions. How are protein interactions organized at the scale of the whole cell? Are there global principles that
organize such complex networks of interactions? How to understand the global topological features of networks and what they mean? And how is the organization of cellular networks disrupted in human disease?
The long-term goal of CCSB is to understand how macromolecular networks control biological processes and how we can better understand human disease through perturbations of such networks. Physical protein-protein interactions are instrumental for all biological processes. We address several fundamental questions regarding protein interactions. How are protein interactions organized at the scale of the whole cell? Are there global principles that
organize such complex networks of interactions? How to understand the global topological features of networks and what they mean? And how is the organization of cellular networks disrupted in human disease?
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