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About Miketitle
Scientific Director of CCSB Department of Cancer Biology education Ph.D., University of Leeds, United Kingdom 1999 B.Sc., University of Edinburgh, United Kingdom 1995 contact Info Michael_Calderwood@dfci.harvard.edu +My Bibliography |
The aim of my research is to understand how protein-protein interactions underlie biological processes and how perturbations in these interaction networks can result in disease. Proteins physically interact with one another to form molecular machines, signaling pathways and cellular structures that underlie most of the functions of the cell. By understanding how protein interactions are organized at the scale of the whole cell rather than in isolation, we can provide a better understanding of the functional and dynamic aspects of biological systems and reveal how disease alleles perturb the network. As a post-doctoral fellow in the laboratory of Prof. Elliot Kieff, I applied a high-throughput binary protein-protein interaction mapping approach to generate the first systematic map of protein-protein interactions for Epstein-Barr virus (EBV). I now lead the interactome mapping team at the Center for Cancer Systems Biology (CCSB) where we are systematically mapping protein-protein interactions, both in human and in several model organisms. Such large scale unbiased systematic interactome maps are the key to understanding global properties of the network and functionally connect genetic perturbations in human disease with their phenotypic consequences.